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da Silva JS;  Gabriel-Costa D;  Sudo RT;  Wang H;  Groban L;  Ferraz EB;  Nascimento JHM;  Fraga CAM;  Barreiro EJ;  Zapata-Sudo G; Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. Drug Design, Development and Therapy (2017) 11, 553-562

Carvalho VF;  Ferreira TP;  de Arantes ACS;  Noël F;  Tesch R;  Sant'Anna CMR; Barreiro EJ;  Fraga CAM;   Rodrigues e Silva PM;  Martins MA; LASSBio-897 reduces lung injury induced by silica particles in Mice: Potential interaction with the A2A receptor. Frontiers (2017) 8,  778

Alencar AK;  Montes GC;  Montagnoli T;  Silva AM;  Martinez ST;  Fraga AG;  Wang H;  Groban L; Sudo RT; Zapata-Sudo G; Activation of GPER ameliorates experimental pulmonary hypertension in male rats. European Journal of Pharmaceutical Sciences (2017) 97, 208-217

Betti AH;  Antonio CB;  Pompeu TET; Martins TS;  Herzfeldt V;  Stolz ED; Fraga CAM; Barreiro EJ;  Noël F;  Rates SMK; LASSBio-1422: A new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition. Behavioural Pharmacology (2017) 28, 48-62

Silva JR;  Lopes AH; Talbot J;  Cecilio NT;  Rossato MF;  Silva RL;  Souza GR;  Silva CR;  Lucas G;  Fonseca BA; Arruda E;  Alves-Filho JC; Cunha FQ; Cunha TM; Neuroimmune–glia interactions in the sensory ganglia account for the development of acute herpetic neuralgia. Journal of Neuroscience (2017) 37, 6408-6422

Wang H;  Sun X.;  Chou J;  Lin M;  Ferrario CM;  Zapata-Sudo G;  Groban L.; Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis. Biochimica et Biophysica Acta - Molecular Basis of Disease (2017) 1863, 1870-1882

 

 

Krake SH; Martinez PDG; McLaren J; Ryan E; Chen G; White K;  Charman SA; Campbell S; Willis P;  Dias LC; Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans. European Journal of Medicinal Chemistry (2017) 126, 929-936

Trevelin SC;  Carlos D;  Beretta M; da Silva JS;  Cunha FQ; Diabetes mellitus and sepsis: A challenging association. Shock (2017) 47, 276-286

Montes GC; da Silva BNM;  Rezende B;  Sudo RT; Ferreira VF;  da Silva, FC;  Pinto AC;  da Silva BV;  Zapata-Sudo G; The hypnotic, anxiolytic, and antinociceptive profile of a novel μ-opioid agonist. Molecules (2017) 22, 800

Bastos ITS;  Costa FN;  Silva TF;  Barreiro EJ;  Lima LM; Braz D; Lombardo GM;  Punzo F;  Ferreira FF;  Barroso RC; A combined experimental and in silico characterization to highlight additional structural features and properties of a potentially new drug. Journal of Molecular Structure (2017) 1146, 735-743

de Araújo MV;  David CC;  Neto JC;  de Oliveira LAPL; da Silva KCJ; dos Santos JM; da Silva JKS; Brandão VBC;  Silva TMS;  Camara CA; Alexandre-Moreira MS; Evaluation on the leishmanicidal activity of 2-N,N′-dialkylamino-1,4-naphthoquinone derivatives. Experimental Parasitology (2017) 176, 46-51

Serafim RAM; de Oliveira TF; Loureiro APM; Krogh R;  Andricopulo AD; Dias LC; Ferreira EI; Molecular modeling and structure–activity relationships studies of bioisoster hybrids of N-acylhydrazone and furoxan groups on cruzain. Medicinal Chemistry Research (2017) 26, 760-769

Coutinho DS; Anjos-Valotta EA;  do Nascimento CVM;  Pires ALA; Napimoga MH;  Carvalho VF; Torres RC; Silva PMR;  Martins MA; 15-deoxy-delta-12,14-Prostaglandin J2 inhibits lung inflammation and remodeling in distinct murine models of Asthma. Frontiers in Immunology (2017) 8, 740

Ibiapino AL; de Figueiredo LP;  Lima LM; Barreiro EJ;  Punzo F;  Ferreira FF; Structural and physicochemical characterization of sulfonylhydrazone derivatives designed as hypoglycemic agents. New Journal of Chemistry (2017) 41: 6464-6474

Dias LC;  Polo EC; Nhatrangin A: Total Syntheses of the Proposed Structure and Six of Its Diastereoisomers. Journal of Organic Chemistry (2017) 82, 4072-4112

 

Oliveira AA;  Perdigão GMC; Rodrigues LE; da Silva JG;  Souza-Fagundes EM; Takahashi JÁ;  Rocha WR;  Beraldo H; Cytotoxic and antimicrobial effects of indium(iii) complexes with 2-acetylpyridine-derived thiosemicarbazones. Dalton Transactions (2017) 46, 918-932

Oliveira AA; Perdigão GMC; da Silva JG; Souza-Fagundes EM;  Beraldo H; Indium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones exhibit cytotoxic activity against human leukemia and solid tumor cell lines. Polyhedron (2017) 135, 72-78

Serafim RAM;  Pernichelle FG; Ferreira EI; The latest advances in the discovery of nitric oxide hybrid drug compounds. Expert Opinion on Drug Discovery (2017) 12, 941-953

                                                                      

Instituto Nacional de Ciência e Tecnologia em Fármacos e Medicamentos (INCT-INOFAR)
Instituto de Ciências Biomédicas (ICB)
Universidade Federal do Rio de Janeiro (UFRJ)
Centro de Ciências da Saúde (CCS)
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