Publicações 2018

FREITAS, ROSANA H. C. N. ; CORDEIRO, NATÁLIA M. ; CARVALHO, PATRÍCIA R. ; Alves, Marina A. ; GUEDES, ISABELLA A. ; VALERIO, TAYNA S. ; DARDENNE, LAURENT E. ; LIMA, LÍDIA M. ; Barreiro, Eliezer J. ; FERNANDES, PATRÍCIA D. ; Fraga, Carlos A. M. . Discovery of naphthyl- N -acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity. Chemical Biology & Drug Design, v. June, p. 1-7, 2018.

THOTA, SREEKANTH ; RODRIGUES, DANIEL A ; CRANS, DEBBIE C ; Barreiro, Eliezer J. . Ru(II) Compounds: Next-generation anticancer metallotherapeutics?. Journal of Medicinal Chemistry, v. 46, p. 000-000, 2018.

Casquilho, Natália V. ; MOREIRA-GOMES, MARIA DIANA ; MAGALHÃES, CLARISSA B. ; OKURO, RENATA T. ; ORTENZI, VICTOR HUGO ; FEITOSA-LIMA, EMANUEL K. ; Lima, Lidia M. ; Barreiro, Eliezer J. ; Soares, Raquel M. ; Azevedo, Sandra M.F.O. ; Valença, Samuel S. ; FORTUNATO, RODRIGO S. ; CARVALHO, ALYSSON RONCALLY ; Zin, Walter A. . Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized. TOXICON, v. 144, p. 75-82, 2018.

HERRMANN, SONJA ; SCHÜBEL, TABEA ; COSTA, FANNY N. ; BARBOSA, MARIA LETÍCIA C. ; FERREIRA, FABIO F. ; DIAS, THAYS L.M.F. ; ARAÚJO, MORGANA V. ; Alexandre-Moreira, Magna S. ; LIMA, LÍDIA M. ; LAUFER, STEFAN ; Barreiro, Eliezer J. . Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones. ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, v. 90, p. 1073-1088, 2018.

AMARAL, D. N. ; SANTANNA, Carlos M R ; Cavalcanti, B. C. ; Pessoa C. O. ; LIMA, L. M. ; Barreiro, E.J. . Synthesis, Pharmacological Evaluation and Docking Study of a New. Letters in Drug Design and Discovery, v. 15, p. 778-786, 2018.

THOTA, SREEKANTH ; Rodrigues, Daniel A. ; PINHEIRO, PEDRO DE SENA MURTEIRA ; LIMA, LÍDIA M. ; FRAGA, CARLOS A.M. ; Barreiro, Eliezer J. . N-Acylhydrazones as drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 28, p. 2797-2806, 2018.

GUIMARÃES, ELISALVA TEIXEIRA ; DOS SANTOS, TATIANA BARBOSA ; SILVA, DAHARA KEYSE CARVALHO ; MEIRA, CÁSSIO SANTANA ; MOREIRA, DIOGO RODRIGO MAGALHÃES ; DA SILVA, TIAGO FERNANDES ; SALMON, DIDIER ; Barreiro, Eliezer J. ; SOARES, MILENA BOTELHO PEREIRA . Potent immunosuppressive activity of a phosphodiesterase-4 inhibitor N-acylhydrazone in models of lipopolysaccharide-induced shock and delayed-type hypersensitivity reaction. INTERNATIONAL IMMUNOPHARMACOLOGY, v. 65, p. 108-118, 2018.

COSTA, FABIANA BETTANIN ; CORTEZ, ALANE P. ; DE ÁVILA, RENATO IVAN ; DE CARVALHO, FLÁVIO S. ; ANDRADE, WANESSA M. ; DA CRUZ, ANDREZZA F. ; REIS, KARINNA B. ; Menegatti, Ricardo ; Lião, Luciano M. ; ROMEIRO, LUIZ ANTÔNIO S. ; Noël, François ; FRAGA, CARLOS ALBERTO M. ; Barreiro, Eliezer J. ; SANZ, GERMÁN ; RODRIGUES, MARCELLA F. ; VAZ, BONIEK G. ; VALADARES, MARIZE CAMPOS . The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D 4 receptor binding and toxicological assessment. BIOMEDICINE & PHARMACOTHERAPY, v. 102, p. 481-493, 2018.

BASTOS, ISADORA ; PINHEIRO, PEDRO ; COSTA, FANNY ; ROCHA, MIGUEL ; SANT?ANNA, CARLOS ; BRAZ, DELSON ; SOUZA, EVERTON ; MARTINS, MARCO ; Barreiro, Eliezer ; FERREIRA, FABIO ; BARROSO, REGINA ; FRAGA, CARLOS . Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative. PHARMACEUTICALS, v. 11, p. 119-135, 2018.

MARINHO, POLYANA C. ; VIEIRA, ALINE B. ; PEREIRA, PRISCILA G. ; RABELO, KÍSSILA ; CIAMBARELLA, BIANCA T. ; NASCIMENTO, ANA L. R. ; CORTEZ, ERIKA ; MOURA, ANÍBAL S. ; GUIMARÃES, FERNANDA V. ; Martins, Marco A. ; BARQUERO, GONZALO ; FERREIRA, RODRIGO N. ; DE CARVALHO, JORGE J. . Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease. Evidence-based Complementary and Alternative Medicine, v. 2018, p. 1-9, 2018.

Carvalho, Vinicius F. ; Barreto, Emiliano O. ; ARANTES, ANA CAROLINA S. ; Serra, Magda F. ; FERREIRA, TATIANA PAULA T. ; JANNINI-SÁ, YAGO A. P. ; HOGABOAM, CORY M. ; Martins, Marco A. ; SILVA, PATRÍCIA M. R. . Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. MEDIATORS OF INFLAMMATION, v. 2018, p. 1-11, 2018.

BASTOS, ISADORA ; PINHEIRO, PEDRO ; COSTA, FANNY ; ROCHA, MIGUEL ; SANT?ANNA, CARLOS ; BRAZ, DELSON ; SOUZA, EVERTON ; Martins, Marco ; BARREIRO, Eliezer ; FERREIRA, FABIO ; BARROSO, REGINA ; FRAGA, CARLOS . Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative. PHARMACEUTICALS, v. 11, p. 119-14, 2018.

ALENCAR, A. K. N. ; PIMENTEL-COELHO, P. M. ; MONTES, G. C. ; MENDES, L. V. ; MONTAGNOLI, T. L. ; SILVA, M. M. ; SILVA, A. ; TOLEDO, M. F. ; CUNHA, V. N. ; FRAGA, A. G. M. ; e Silva, P. M. R. ; MARTINS, M A ; Ferreira, T. P. T. ; MENDES-OTERO, R. ; TRACHEZ, M. M. ; Sudo, R.T. ; ZAPATA-SUDO, G. . Human mesenchymal stem cell therapy reverses Su5416/hypoxia-induced pulmonary arterial hypertension in mice. Frontiers in Pharmacology, v. 9, p. 1-16, 2018.

Serra, Magda F. ; Cotias, Amanda C. ; PÃO, CAMILA R. R. ; DALEPRANE, JULIO B. ; Jurgilas, Patricia B. ; Couto, Gina C. ; Anjos-Valotta, Edna A. ; CORDEIRO, RENATO S. B. ; Carvalho, Vinicius F. ; Silva, Patricia M. R. ; Martins, Marco A. . Repeated Allergen Exposure in A/J Mice Causes Steroid-Insensitive Asthma via a Defect in Glucocorticoid Receptor Bioavailability. JOURNAL OF IMMUNOLOGY, v. 201, p. ji1700933-860, 2018.

MARTINEZ, PABLO D.G. ; KRAKE, SUSANN H. ; POGGI, MAITIA L. ; CAMPBELL, SIMON F. ; WILLIS, PAUL A. ; Dias, Luiz C. . 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. ANAIS DA ACADEMIA BRASILEIRA DE CIÊNCIAS (ONLINE), v. 90, p. 1215-1231, 2018.

RODRIGUES, DANIEL A. ; DE SENA M. PINHEIRO, PEDRO ; FERREIRA, THAYSSA T. S. C. ; THOTA, SREEKANTH ; FRAGA, CARLOS A. M. . Structural Basis for the Agonist Action at Free Fatty Acid Receptor 1 (FFA1R or GPR40). Chemical Biology & Drug Design, v. 91, p. 668-680, 2018.

PINHEIRO, PEDRO DE SENA MURTEIRA ; RODRIGUES, DANIEL ALENCAR ; ALVES, MARINA AMARAL ; TINOCO, LUZINEIDE ; FERREIRA, GLAUCIO BRAGA ; SANT?ANNA, CARLOS ; FRAGA, CARLOS ALBERTO MANSSOUR . Theoretical and Experimental Characterization of 1,4-N S σ-hole Intramolecular Interactions in Bioactive N-Acylhydrazone Derivatives. NEW JOURNAL OF CHEMISTRY, v. 42, p. 497-505, 2018.

FREITAS, ROSANA H. C. N. ; CORDEIRO, NATÁLIA M. ; CARVALHO, PATRÍCIA R. ; ALVES, MARINA A. ; GUEDES, ISABELLA A. ; VALERIO, TAYNA S. ; DARDENNE, LAURENT E. ; LIMA, LÍDIA M. ; Barreiro, Eliezer J. ; FERNANDES, PATRÍCIA D. ; FRAGA, CARLOS A. M. . Discovery of naphthyl- N -acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity. Chemical Biology & Drug Design, v. 91, p. 391-397, 2018.

FREITAS, ROSANA H.C.N. ; FRAGA, CARLOS A.M. . NF-κB-IKKβ pathway as a target for drug development: realities, challenges and perspectives. CURRENT DRUG TARGETS, v. 19, p. 1933-1942, 2018.

COSTA, FABIANA BETTANIN ; CORTEZ, ALANE P. ; DE ÁVILA, RENATO IVAN ; DE CARVALHO, FLÁVIO S. ; ANDRADE, WANESSA M. ; DA CRUZ, ANDREZZA F. ; REIS, KARINNA B. ; MENEGATTI, Ricardo ; LIÃO, LUCIANO M. ; ROMEIRO, LUIZ ANTÔNIO S. ; NOËL, FRANÇOIS ; FRAGA, CARLOS ALBERTO M. ; Barreiro, Eliezer J. ; SANZ, GERMÁN ; RODRIGUES, MARCELLA F. ; VAZ, BONIEK G. ; VALADARES, MARIZE CAMPOS . The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D 4 receptor binding and toxicological assessment. BIOMEDICINE & PHARMACOTHERAPY, v. 102, p. 481-493, 2018.

ALENCAR, ALLAN K. ; CARVALHO, FÁBIO I. ; SILVA, ANANSSA M. ; MARTINEZ, SABRINA T. ; CALASANS-MAIA, JORGE A. ; FRAGA, CARLOS M. ; Barreiro, Eliezer J. ; ZAPATA-SUDO, GISELE ; SUDO, ROBERTO T. . Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats. PLoS One, v. 13, p. e0195047, 2018.

TESCH, ROBERTA ; BECKER, CHRISTIAN ; MÜLLER, MATTHIAS PHILIPP ; BECK, MICHAEL EDMUND ; QUAMBUSCH, LENA ; GETLIK, MATTHÄUS ; LATEGAHN, JONAS ; UHLENBROCK, NIKLAS ; COSTA, FANNY NASCIMENTO ; POLÊTO, MARCELO D. ; DE SENA MURTEIRA PINHEIRO, PEDRO ; RODRIGUES, DANIEL ALENCAR ; SANT?ANNA, CARLOS MAURICIO ; FERREIRA, FABIO FURLAN ; VERLI, Hugo ; FRAGA, CARLOS ALBERTO MANSSOUR ; RAUH, DANIEL . An Unusual Intramolecular Halogen Bond guides Conformational Selection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 57, p. 9970-9975, 2018.

THOTA, SREEKANTH ; RODRIGUES, DANIEL A. ; DE SENA MURTEIRA PINHEIRO, PEDRO ; LIMA, LÍDIA M. ; FRAGA, CARLOS A.M. ; Barreiro, Eliezer J. . N -Acylhydrazones as Drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 28, p. 2797-2806, 2018.

OLIVEIRA, RAMON GUERRA DE ; GUERRA, FABIANA SÉLOS ; MERMELSTEIN, CLÁUDIA DOS SANTOS ; FERNANDES, PATRÍCIA DIAS ; BASTOS, ISADORA TAIRINNE DE SENA ; COSTA, FANNY NASCIMENTO ; BARROSO, REGINA CELY RODRIGUES ; FERREIRA, FABIO FURLAN ; FRAGA, CARLOS ALBERTO MANSSOUR . Synthesis and pharmacological evaluation of novel isoquinoline N -sulphonylhydrazones designed as ROCK inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v. 33, p. 1181-1193, 2018.

BASTOS, ISADORA ; PINHEIRO, PEDRO ; COSTA, FANNY ; ROCHA, MIGUEL ; SANT?ANNA, CARLOS ; BRAZ, DELSON ; SOUZA, EVERTON ; MARTINS, MARCO ; BARREIRO, ELIEZER ; FERREIRA, FABIO ; BARROSO, REGINA ; FRAGA, CARLOS . Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative. PHARMACEUTICALS, v. 11, p. 119, 2018.

PINHEIRO, PEDRO DE SENA MURTEIRA ; RODRIGUES, DANIEL ALENCAR ; SANT'ANNA, CARLOS MAURICIO R. ; FRAGA, CARLOS ALBERTO MANSSOUR . Modeling zinc-oxygen coordination in histone deacetylase: A comparison of semiempirical methods performance. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, v. 118, p. e25720, 2018.

OLIVEIRA, VINÍCIUS ROSA ; CARVALHO, GIOVANNA MARCELLA CAVALCANTE ; CASQUILHO, NATÁLIA VASCONCELOS ; MOREIRA-GOMES, MARIA DIANA ; SOARES, RAQUEL MORAES ; AZEVEDO, SANDRA MARIA F.O. ; Lima, Lidia Moreira ; Barreiro, Eliezer Jesus ; TAKIYA, CHRISTINA MAEDA ; ZIN, Walter Araujo . Lung and liver responses to 1- and 7-day treatments with LASSBio-596 in mice subchronically intoxicated by microcystin-LR. TOXICON, v. 141, p. 1-8, 2018.

de Oliveira Lopes, Raquel ; Alves, Marina Amaral ; PINHEIRO, ROBERTA OLMO ; FREITAS, CRISTINA SETIM ; Cunha, Fernando Q. ; Barreiro, Eliezer J. ; LIMA, LÍDIA MOREIRA . Synthesis, Aqueous Solubility, Metabolic Stability and Pharmacological Profile of Simplified Urea Derivatives. Letters in Drug Design & Discovery, v. 15, p. 766-777, 2018.

THOTA, SREEKANTH ; RODRIGUES, DANIEL A. ; PINHEIRO, PEDRO DE SENA MURTEIRA ; Lima, Lídia M. ; FRAGA, CARLOS A.M. ; Barreiro, Eliezer J. . N-Acylhydrazones as drugs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v. 28, p. 2797-2806, 2018.

Casquilho, Natália V. ; MOREIRA-GOMES, MARIA DIANA ; MAGALHÃES, CLARISSA B. ; OKURO, RENATA T. ; ORTENZI, VICTOR HUGO ; FEITOSA-LIMA, EMANUEL K. ; Lima, Lidia M. ; Barreiro, Eliezer J. ; Soares, Raquel M. ; Azevedo, Sandra M.F.O. ; Valença, Samuel S. ; FORTUNATO, RODRIGO S. ; CARVALHO, ALYSSON RONCALLY ; Zin, Walter A. . Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized. TOXICON, v. 144, p. 75-82, 2018.

CARNEIRO, TEILIANE R. ; do Amaral, Daniel N. ; FOKOUE, HAROLD H. ; SANT`ANNA, CARLOS M.R. ; PORRAS, MARIA L.G. ; OLIVEIRA, AUGUSTO C.A. ; C. CAVALCANTI, BRUNO ; PESSOA, CLAUDIA ; Barreiro, Eliezer J. ; Lima, Lidia M. . Synthesis, Pharmacological Evaluation and Docking Study of a New Modulator of Microtubule Polymerization. Letters in Drug Design & Discovery, v. 15, p. 778-786, 2018.

FREITAS, ROSANA H. C. N. ; CORDEIRO, NATÁLIA M. ; CARVALHO, PATRÍCIA R. ; Alves, Marina A. ; GUEDES, ISABELLA A. ; VALERIO, TAYNA S. ; DARDENNE, LAURENT E. ; Lima, Lídia M. ; Barreiro, Eliezer J. ; FERNANDES, PATRÍCIA D. ; FRAGA, CARLOS A. M. . Discovery of naphthyl- N -acylhydrazone p38α MAPK inhibitors with in vivo anti-inflammatory and anti-TNF-α activity. Chemical Biology & Drug Design, v. 91, p. 391-397, 2018.

PAIER, CR ; MARANHÃO, SS ; CARNEIRO, TR ; LIMA, LM ; ROCHA, DD ; SANTOS, RS ; FARIAS, KM ; MORAES-FILHO, MO ; PESSOA, C . Natural products as new antimitotic compounds for anticancer drug development. Clinics, v. 73, p. e813s, 2018.

HERRMANN, SONJA ; SCHÜBEL, TABEA ; COSTA, FANNY N. ; BARBOSA, MARIA LETÍCIA C. ; FERREIRA, FABIO F. ; DIAS, THAYS L.M.F. ; ARAÚJO, MORGANA V. ; Alexandre-Moreira, Magna S. ; Lima, Lídia M. ; LAUFER, STEFAN ; Barreiro, Eliezer J. . Synthesis, X-ray diffraction study and pharmacological evaluation of 3-amino-4-methylthiophene-2-acylcarbohydrazones. ANAIS DA ACADEMIA BRASILEIRA DE CIÊNCIAS (ONLINE), v. 90, p. 1073-1088, 2018.

ALENCAR, ALLAN K. ; CARVALHO, FÁBIO I. ; SILVA, ANANSSA M. ; MARTINEZ, SABRINA T. ; CALASANS-MAIA, JORGE A. ; FRAGA, CARLOS M. ; Barreiro, Eliezer J. ; Zapata-Sudo, Gisele ; Sudo, Roberto T. . Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats. PLoS One, v. 13, p. e0195047, 2018.

ALENCAR, ALLAN K. N. ; PIMENTEL-COELHO, PEDRO M. ; MONTES, GUILHERME C. ; DA SILVA, MARINA DE M. C. ; MENDES, LUIZA V. P. ; MONTAGNOLI, TADEU L. ; SILVA, ANANSSA M. S. ; VASQUES, JULIANA FERREIRA ; ROSADO-DE-CASTRO, PAULO HENRIQUE ; GUTFILEN, BIANCA ; CUNHA, VALÉRIA DO M. N. ; FRAGA, ALINE G. M. ; SILVA, PATRÍCIA M R E ; MARTINS, MARCO AURÉLIO ; FERREIRA, TATIANA PAULA TEIXEIRA ; MENDES-OTERO, ROSALIA ; TRACHEZ, MARGARETE M. ; Sudo, Roberto T. ; Zapata-Sudo, Gisele . Human Mesenchymal Stem Cell Therapy Reverses Su5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Mice. Frontiers in Pharmacology, v. 9, p. 1-16, 2018.

Borsoi, Milene ; BATASSINI, CRISTIANE ; LAZZARETTI, CAMILLA ; SILVESTRIN, ROBERTA BRISTOT ; BETTI, Andresa Heemann ; Stein, Ana Cristina ; von Poser, Gilsane Lino ; RATES, STELA MARIS KUZE ; E SOUZA, TADEU MELLO . Hypericum polyanthemum cyclohexane extract potentiates behavioral effects and neurodegeneration induced by nigral infusions of 6-hydroxydopamine in rats. NEUROSCIENCE LETTERS, v. 18, p. 30652-30659, 2018.

PAIER, CR ; MARANHÃO, SS ; CARNEIRO, TR ; Lima, LM ; ROCHA, DD ; SANTOS, RS ; FARIAS, KM ; MORAES-FILHO, MO ; PESSOA, C . Natural products as new antimitotic compounds for anticancer drug development. Clinics, v. 73, p. 1-11, 2018.

BRITO, A. ; BRAGA, P. ; MOREIRA, L. ; SILVA, D. ; SILVA, D. ; GERMAN, S. ; GONTIJO, B. ; CARVALHO, F. ; LIAO, L. ; SILVA, R. R. ; Noël, F. ; NERI, H. ; GHEDINI, P. C. ; CARVALHO, M. ; GIL, E. ; COSTA, E. ; MENEGATTI, R. . A NEW PIPERAZINE DERIVATIVE: 1-(4-(3,5-DI-TERT-BUTYL-4- HYDROXYBENZYL) PIPERAZIN-1-YL)-2-METHOXYETHAN-1-ONE WITH ANTIOXIDANT AND CENTRAL ACTIVITY. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 391, p. 255-269, 2018.

COSTA, F. ; CORTEZ, A. ; AVILA, R. ; CARVALHO, F. ; ANDRADE, W. ; CRUZ, A. ; REIS, K. ; MENEGATTI, R. ; LIAO, L. ; ROMEIRO, L. A. S. ; NOEL, FRANÇOIS ; FRAGA, C. A. M. ; BARREIRO, E. J. ; SANZ, G. ; RODRIGUES, M. ; VAZ, B. ; VALADARES, M. . The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment. BIOMEDICINE & PHARMACOTHERAPY, v. 102, p. 481-493, 2018.

DE FREITAS SILVA, MATHEUS ; COELHO, LETÍCIA FERREIRA ; GUIRELLI, ISADORA MITESTAINER ; PEREIRA, RODRIGO MACHADO ; DA SILVA, GUILHERME ÁLVARO FERREIRA ; GRARAVELLI, GRACIANA Y. ; DE OLIVEIRA HORVATH, RENATO ; NOGUEIRA, ESTER SIQUEIRA CAIXETA ; IONTA, MARISA ; VIEGAS, CLAUDIO . Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive mcf-7 breast cancer cells. TOXICOLOGY IN VITRO, v. 50, p. 75-85, 2018.

Silva, J. C. ; OLIVEIRA JUNIOR, R. G. ; SILVA, M. G. E. ; LAVOR, E. M. ; SOARES, J. M. D. ; LIMA-SARAIVA, S. R. G. ; DINIZ, T. C. ; Mendes, R. L. ; ALENCAR FILHO, E. B. ; BARREIRO, E. J. L. ; LIMA, L. M. ; ALMEIDA, J. R. G. S. . LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. PLoS One, v. 13, p. e0199009-19, 2018.

CHAVES, OTÁVIO ; FERREIRA, ROMULO ; DA SILVA, LORRAYNE ; DE SOUZA, BRUNA ; CESARIN-SOBRINHO, DARI ; NETTO-FERREIRA, JOSÉ CARLOS ; SANT?ANNA, CARLOS ; FERREIRA, AURÉLIO . Multiple Spectroscopic and Theoretical Approaches to Study the Interaction between HSA and the Antiparasitic Drugs: Benznidazole, Metronidazole, Nifurtimox and Megazol. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, v. 29, p. 1551-1562, 2018.

TESCH, ROBERTA ; BECKER, CHRISTIAN ; MÜLLER, MATTHIAS PHILIPP ; BECK, MICHAEL EDMUND ; QUAMBUSCH, LENA ; GETLIK, MATTHÄUS ; LATEGAHN, JONAS ; UHLENBROCK, NIKLAS ; COSTA, FANNY NASCIMENTO ; POLÊTO, MARCELO D. ; DE SENA MURTEIRA PINHEIRO, PEDRO ; RODRIGUES, DANIEL ALENCAR ; SANT?ANNA, CARLOS MAURICIO ; FERREIRA, FABIO FURLAN ; VERLI, HUGO ; FRAGA, Carlos Alberto Manssour ; RAUH, DANIEL . An Unusual Intramolecular Halogen Bond guides Conformational Selection. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 57, p. 9970-9975, 2018.

BASTOS, ISADORA ; PINHEIRO, PEDRO ; COSTA, FANNY ; ROCHA, MIGUEL ; SANT?ANNA, CARLOS ; BRAZ, DELSON ; SOUZA, EVERTON ; MARTINS, MARCO ; BARREIRO, ELIEZER ; FERREIRA, FABIO ; BARROSO, REGINA ; FRAGA, CARLOS . Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative. PHARMACEUTICALS, v. 11, p. 119-123, 2018

SOUSA-PEREIRA, DANILO ; CHAVES, OTÁVIO AUGUSTO ; DOS REIS, CAMILLA MORETTO ; DE OLIVEIRA, MÁRCIA C.C. ; SANT'ANNA, CARLOS MAURÍCIO R. ; NETTO-FERREIRA, JOSÉ CARLOS ; ECHEVARRIA, Aurea . Synthesis and biological evaluation of N-aryl-2-phenyl-hydrazinecarbothioamides: Experimental and theoretical analysis on tyrosinase inhibition and interaction with HSA. BIOORGANIC CHEMISTRY, v. 81, p. 79-87, 2018.

PINHEIRO, PEDRO DE SENA MURTEIRA ; RODRIGUES, DANIEL ALENCAR ; Sant'Anna, Carlos Mauricio R. ; FRAGA, Carlos Alberto Manssour . Modeling zinc-oxygen coordination in histone deacetylase: A comparison of semiempirical methods performance. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, v. 118, p. e25720, 2018.

DIAS VIEGAS, FLÁVIA PEREIRA DE FREITAS SILVA, MATHEUS DIVINO DA ROCHA, MIGUEL CASTELLI, MAÍSA ROSA RIQUIEL, MARIANA MÁXIMO MACHADO, RAFAEL PEREIRA VAZ, SARAH MACEDO SIMÕES DE LIMA, LAÍS MEDEIROS MANCINI, KARLA CRISTINE MARQUES DE OLIVEIRA, PATRÍCIA CRUZ MORAIS, ÉLIDA PARREIRA GONTIJO, VANESSA SILVA DA SILVA, FERNANDA MOTTA R. D'ALINCOURT DA FONSECA PEÇANHA, DORA CASTRO, NEWTON GONÇALVES NEVES, GILDA A. GIUSTI-PAIVA, ALEXANDRE VILELA, FABIANA CARDOSO ORLANDI, LIDIANE CAMPS, IHOSVANY VELOSO, MÁRCIA PARANHO LEOMIL COELHO, LUIS FELIPE IONTA, MARISA FERREIRA-SILVA, GUILHERME ÁLVARO PEREIRA, RODRIGO MACHADO , et al. ; Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 147, p. 48-65, 2018.

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DE CASTRO SANT’ ; JUNIOR, ALBERTO GOMES FERREIRA ; SOARES, PAULO ; TUJI, FABRICIO ; PASCHOAL, ERIC ; CHAVES, LUIZ CLÁUDIO ; Burbano, Rommel Rodriguez . Molecular biology as a tool for the treatment of cancer. CLINICAL AND EXPERIMENTAL MEDICINE, v. 18, p. 457-464, 2018.

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